| Boogey |
In Mission Mode beat Mission 9 in "Tier 4" |
| Chicken |
Beat Story Mode with all characters on any difficulty with 10 hours of gameplay |
| Clown |
Battle 100 times in Versus Mode |
| Dracula |
In Mission Mode beat Mission 5 in "Tier 3" |
| Eris |
Beat "Story Mode" once with either Billy, Mandy, Grim, Or Irwin |
| Fred Fredburger |
Beat "Story Mode" once with either Billy, Mandy, Grim, Or Irwin |
| General Skarr |
In Mission Mode beat Mission 6 in "Tier 4" |
| Hoss Delgado |
Beat Mission 9 in Tier 1 in "Mission Mode" |
| Jack O'Lantern |
In Mission Mode beat Mission 9 in "Tier 2" |
| Lord Pain |
Complete Mission 9 in Tier 5 |
| Mogar |
Beat "Story Mode" once with either Billy, Mandy, Grim, Or Irwin |
| Nergal |
Beat "Story Mode" once with either Billy, Mandy, Grim, Or Irwin |
| Nergal Jr. |
In Mission Mode beat Mission 9 in "Tier 3" |
| Nerglings |
Beat Story Mode with all characters on any difficulty |
| Pumpkin |
Get 100,000 damage in Vs. Mode and have all characters complete Story Mode |
| Vikings |
Beat Story Mode with all characters and destroy every letter in the credits sequence |